Open-Loop Spatial Multiplexing and Diversity Communications in Ad Hoc Networks

This paper investigates the performance of open-loop multi-antenna point-to-point links in ad hoc networks with slotted ALOHA medium access control (MAC). We consider spatial multiplexing transmission with linear maximum ratio combining and zero forcing receivers, as well as orthogonal space time block coded transmission. New closed-form expressions are derived for the outage probability, throughput and transmission capacity. Our results demonstrate that both the best performing scheme and the optimum number of transmit antennas depend on different network parameters, such as the node intensity and the signal-to-interference-and-noise ratio operating value. We then compare the performance to a network consisting of single-antenna devices and an idealized fully centrally coordinated MAC. These results show that multi-antenna schemes with a simple decentralized slotted ALOHA MAC can outperform even idealized single-antenna networks in various practical scenarios.Comment: 51 pages, 19 figures, submitted to IEEE Transactions on Information Theor

Autonomous Demand Side Management Based on Energy Consumption Scheduling and Instantaneous Load Billing: An Aggregative Game Approach

In this paper, we investigate a practical demand side management scenario where the selfish consumers compete to minimize their individual energy cost through scheduling their future energy consumption profiles. We propose an instantaneous load billing scheme to effectively convince the consumers to shift their peak-time consumption and to fairly charge the consumers for their energy consumption. For the considered DSM scenario, an aggregative game is first formulated to model the strategic behaviors of the selfish consumers. By resorting to the variational inequality theory, we analyze the conditions for the existence and uniqueness of the Nash equilibrium (NE) of the formulated game. Subsequently, for the scenario where there is a central unit calculating and sending the real-time aggregated load to all consumers, we develop a one timescale distributed iterative proximal-point algorithm with provable convergence to achieve the NE of the formulated game. Finally, considering the alternative situation where the central unit does not exist, but the consumers are connected and they would like to share their estimated information with others, we present a distributed agreement-based algorithm, by which the consumers can achieve the NE of the formulated game through exchanging information with their immediate neighbors.Comment: 11 pages, 7 figure

Relay Selection with Network Coding in Two-Way Relay Channels

In this paper, we consider the design of joint network coding (NC)and relay selection (RS) in two-way relay channels. In the proposed schemes, two users first sequentially broadcast their respective information to all the relays. We propose two RS schemes, a single relay selection with NC and a dual relay selection with NC. For both schemes, the selected relay(s) perform NC on the received signals sent from the two users and forward them to both users. The proposed schemes are analyzed and the exact bit error rate (BER) expressions are derived and verified through Monte Carlo simulations. It is shown that the dual relay selection with NC outperforms other considered relay selection schemes in two-way relay channels. The results also reveal that the proposed NC relay selection schemes provide a selection gain compared to a NC scheme with no relay selection, and a network coding gain relative to a conventional relay selection scheme with no NC.Comment: 11 pages, 5 figure

Analysis and Design of Multiple-Antenna Cognitive Radios with Multiple Primary User Signals

We consider multiple-antenna signal detection of primary user transmission signals by a secondary user receiver in cognitive radio networks. The optimal detector is analyzed for the scenario where the number of primary user signals is no less than the number of receive antennas at the secondary user. We first derive exact expressions for the moments of the generalized likelihood ratio test (GLRT) statistic, yielding approximations for the false alarm and detection probabilities. We then show that the normalized GLRT statistic converges in distribution to a Gaussian random variable when the number of antennas and observations grow large at the same rate. Further, using results from large random matrix theory, we derive expressions to compute the detection probability without explicit knowledge of the channel, and then particularize these expressions for two scenarios of practical interest: 1) a single primary user sending spatially multiplexed signals, and 2) multiple spatially distributed primary users. Our analytical results are finally used to obtain simple design rules for the signal detection threshold.Comment: Revised version (14 pages). Change in titl

Breathing adapted radiotherapy: a 4D gating software for lung cancer

<p>Abstract</p> <p>Purpose</p> <p>Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy (RT). The optimal respiratory phase for beam-on may be assessed with a respiratory phase optimizer (RPO), a 4D image processing software developed with this purpose.</p> <p>Methods and Materials</p> <p>Fourteen patients with lung cancer were included in the study. Every patient underwent a 4D-CT providing ten datasets of ten phases of the respiratory cycle (0-100% of the cycle). We defined two morphological parameters for comparison of 4D-CT images in different respiratory phases: tumor-volume to lung-volume ratio and tumor-to-spinal cord distance. The RPO automatized the calculations (200 per patient) of these parameters for each phase of the respiratory cycle allowing to determine the optimal interval for RT.</p> <p>Results</p> <p>Lower lobe lung tumors not attached to the diaphragm presented with the largest motion with breathing. Maximum inspiration was considered the optimal phase for treatment in 4 patients (28.6%). In 7 patients (50%), however, the RPO showed a most favorable volumetric and spatial configuration in phases other than maximum inspiration. In 2 cases (14.4%) the RPO showed no benefit from gating. This tool was not conclusive in only one case.</p> <p>Conclusions</p> <p>The RPO software presented in this study can help to determine the optimal respiratory phase for gated RT based on a few simple morphological parameters. Easy to apply in daily routine, it may be a useful tool for selecting patients who might benefit from breathing adapted RT.</p

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe

Rare pathogenic variants in WNK3 cause X-linked intellectual disability

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordData availability: All data are available upon request. The sequence variants in WNK3 (NM_004656.3) reported in the paper have been deposited in ClinVar database. Their respective accession numbers (SCV002107163 to SCV002107168) are indicated in Tables 1 and S1.Purpose WNK3 kinase (PRKWNK3) has been implicated in the development and function of the brain via its regulation of the cation-chloride cotransporters, but the role of WNK3 in human development is unknown. Method We ascertained exome or genome sequences of individuals with rare familial or sporadic forms of intellectual disability (ID). Results We identified a total of 6 different maternally-inherited, hemizygous, 3 loss-of-function or 3 pathogenic missense variants (p.Pro204Arg, p.Leu300Ser, p.Glu607Val) in WNK3 in 14 male individuals from 6 unrelated families. Affected individuals had identifier with variable presence of epilepsy and structural brain defects. WNK3 variants cosegregated with the disease in 3 different families with multiple affected individuals. This included 1 large family previously diagnosed with X-linked Prieto syndrome. WNK3 pathogenic missense variants localize to the catalytic domain and impede the inhibitory phosphorylation of the neuronal-specific chloride cotransporter KCC2 at threonine 1007, a site critically regulated during the development of synaptic inhibition. Conclusion Pathogenic WNK3 variants cause a rare form of human X-linked identifier with variable epilepsy and structural brain abnormalities and implicate impaired phospho-regulation of KCC2 as a pathogenic mechanism.Estonian Research CouncilNational Natural Science Foundation of ChinaRoyal SocietySouth Carolina Department of Disabilities and Special Needs (SCDDSN)National Institute of Neurological Disorders and Stroke (NINDS